In a large skillet over medium heat, cook the ground beef until browned and no longer pink, breaking it apart as it cooks.
Drain any excess fat, then season the beef with salt, black pepper, and chili powder. Stir well to combine.
Add the salsa and chopped green chilies to the skillet, stirring to incorporate with the beef. Let simmer for 5 minutes to meld the flavors.
Meanwhile, prepare your creamy macaroni and cheese according to your favorite recipe or package instructions.
Once the beef mixture is ready, gently fold it into the prepared macaroni and cheese until evenly combined.
Stir in the fresh cilantro just before serving for a bright, fresh finish.
Serve hot, optionally garnished with extra cilantro or a dollop of sour cream if desired.